PUMA, just seven points behind CAMPER in fourth overall and with the incentive of racing to their home country, are also in the hunt after notching up yet another podium result in yesterday's inshore battle.
Riding on the high of winning Leg 5, PUMA skipper Ken Read said his crew were ready to get back to the race course.
"I don't want to jinx the fleet but it looks like we could have some really nice sailing," Read said. "It's potentially the first leg of this race that we can say that.
"It looks like we might get some downwind sailing out of Itajaí, we might get some nice trade wind sailing, and maybe some consistent wave patterns.
"Everyone's really psyched to go do some nice sailing."
Groupama skipper Franck Cammas, who has already tasted offshore victory in Leg 4, said he had high hopes for success in Leg 6.
"We can enjoy this leg a lot -- it has a lot of good conditions, a lot of reaching conditions," he said. "It's good for the crew, it's good for the boat. I think we can manage our Volvo Open 70 very well in these conditions."
Despite a disappointing result in the DHL In-Port Race Itajaí, Iker Martínez's Telefónica are the form team offshore with three leg wins from five.
"I hope this is going to be another good leg for us," Martínez said. "It looks like it's going to be interesting from beginning to end so we'll just have to see what the next few weeks hold.
"I'm very confident. The boat is even better than it was in New Zealand. We can't ask for more."
The Leg 6 start also saw a welcome return to offshore racing for Ian Walker's Abu Dhabi Ocean Racing, who had to ship their yacht to Itajaí after it was damaged in the Southern Ocean.
The boat only arrived in Brazil on Thursday and the team's shore crew worked round the clock to give Walker's men a chance to compete for their first offshore leg win.
"Everything we know about is fully under control, so let's hope there aren't any things we don't know about," Walker said.
Leg 6 is littered with challenges including tropical weather systems, strong currents, sweltering heat and the dreaded Doldrums.
The first few days of the race could be crucial as the crews negotiate a potentially violent low pressure system lying in wait in the South Brazil Bight.
From there on in the sailing should mostly be downwind in moderate conditions -- although the teams will always be at risk from South Atlantic squalls.
The crews must also take on the Doldrums, a constantly-moving area of low pressure found a few hundred miles either side of the Equator, notorious for being one of the toughest regions on the planet to sail through.
Once into the northern hemisphere they will face tough tactical decisions, trading off distance for speed in the sprint past the Caribbean to the finish line.
The boats are expected to arrive in Miami around May 6.
Team Sanya, who pulled out of Leg 5 with boat damage, will rejoin the fleet in Miami after carrying out repairs in Savannah.